Conservative management of reproductive cancers. Ovarian protection during treatment

Abstract

Globally, breast cancer is the most common female reproductive cancer. Although alkylating chemotherapy is not part of initial curative-intent treatment in women with other reproductive cancers, it is often used to treat women with curable breast cancer. Chemotherapy-associated ovarian failure (COF) is a potential consequence of this treatment and can cause infertility and increase the risk of cognitive impairment, cardiovascular disease and fractures from reduced bone mineral density. Although cryopreservation of embryos and oocytes is often effective for fertility preservation, this does not prevent COF and its associated complications. Randomised trials, predominantly of women undergoing ..